Roger wrote:

In the Navigation Pane, in Shortcuts, you can create shortcuts to
folders. You can also create groups for organizing the shortcuts.
Normally you create a shortcut or a group and it stays there until
you delete it. Now however if I create shortcuts or groups, then
exit and restart Outlook, all the shortcuts and groups are gone.

If this were happening to me, I'd start with a new mail profile.
--
Brian Tillman